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BIOACTIVE CONCENTRATE, ITS PRODUCING METHOD AND CERTAIN DRUG COMPOSITIONS CONTAINING ALSO CHONDROITIN SULPHATE

INVENTOR(S): IOAN MANZATU, DAN-ETIENNE ARIZAN, VASILE IONITA-MANZATU, MARIAN CARASAVA, MARIA PANAIT, IRINA-GABRIELA SCARLAT

Abstract:

The bioactive concentrate is an active substance-aqueous solution or lyophilized powder-consisting of anti-hyaluronidase and antiinflammatory mucopolysaccharide polymers and an addition of restitutive and anti-hyaluronidase chondroitin sulphate, which has a pH=4-6 and antihyaluronidase activity. The bioactive concentrate producing method consists in a two-phased treatment of animal-originated connective cartilaginous tissues such as bovine and sheep trachea, umbilical cord,young animal tendons, bowels, testicles or sea organisms, with phenol solution and the solution resulting is concentrated by vacuum evaporation and then defatted; after filtering, the supernatant obtained is treated for deproteinization, the ion excess is removed by passing through ion exchanger column, the alcohol solution is concentrated to remove alcochol until reaching a volume of 70% as against the aqueous solution subject to proteinization. Drug compositions contain the bioactive concentrate -solution or in lyophilized state - associated with synergic substances such as : heparin, sodium or lysinacetylsallicylate, ascorbic acid, vitamin E,"I"-like structured water, benzyl alcohol, propylene glycocoll, plant extracts (Achillea, Calendula, Matricaria, Plantago, Hypericum) and usual excipients, being conditioned in the form of intramuscular or intraarticular injections, ointment, gel and suppositories. Finally, the histamines are removed and chondroitin sulphate is added up to the concentration required.